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1-isopropylpiperidin-4-ol
- Name 1-isopropylpiperidin-4-ol
- CAS 5570-78-5
- Purity 99%
Product Details
Manufacturer supply top purity 1-isopropylpiperidin-4-ol 5570-78-5 with GMP standards
- Molecular Formula: C8H17NO
- Molecular Weight: 143.229
- Vapor Pressure: 0.016mmHg at 25°C
- Refractive Index: 1.485
- Boiling Point: 226.6 °C at 760 mmHg
- PKA: 14.88±0.20(Predicted)
- Flash Point: 74.5 °C
- PSA： 23.47000
- Density: 0.976 g/cm3
- LogP: 0.78940
1-isopropylpiperidin-4-ol(Cas 5570-78-5) Usage
|
General Description |
1-isopropylpiperidin-4-ol is a chemical compound with the molecular formula C9H19NO. It is a piperidine derivative and is classified as a tertiary alcohol. 1-isopropylpiperidin-4-ol is used in the synthesis of pharmaceuticals and may have potential applications in medicinal chemistry. Its structure contains a piperidine ring with an isopropyl and an alcohol functional group, which gives it both hydrophobic and hydrophilic properties. The presence of the piperidine ring suggests that it may have biological activity, and further research may be conducted to explore its potential as a drug candidate. |
InChI:InChI=1/C8H17NO/c1-7(2)9-5-3-8(10)4-6-9/h7-8,10H,3-6H2,1-2H3
5570-78-5 Relevant articles
Discovery and Development of N-[4-(1-Cyclobutylpiperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide Dihydrochloride (SUVN-G3031): A Novel, Potent, Selective, and Orally Active Histamine H3 Receptor Inverse Agonist with Robust Wake-Promoting Activity
Nirogi, Ramakrishna,Shinde, Anil,Mohammed, Abdul Rasheed,Badange, Rajesh Kumar,Reballi, Veena,Bandyala, Thrinath Reddy,Saraf, Sangram Keshari,Bojja, Kumar,Manchineella, Sravanthi,Achanta, Pramod Kumar,Kandukuri, Kiran Kumar,Subramanian, Ramkumar,Benade, Vijay,Palacharla, Raghava Choudary,Jayarajan, Pradeep,Pandey, Santoshkumar,Jasti, Venkat
, p. 1203 - 1217 (2019/02/24)
A series of chemical optimizations guide...
NEW BICYCLIC COMPOUND FOR MODULATING G PROTEIN-COUPLED RECEPTORS
-
Paragraph 0329-0331, (2013/10/22)
The present invention relates to a bicyc...
NEW BICYCLIC COMPOUND FOR MODULATING G PROTEIN-COUPLED RECEPTORS
-
Page/Page column 48-49, (2012/07/27)
The present invention relates to a bicyc...
TETRAHYDRONAPHTHYRIDINES AND AZA DERIVATIVES THEREOF AS HISTAMINE H3 RECEPTOR ANTAGONISTS
-
Page/Page column 69, (2009/10/30)
The invention relates to compounds of fo...
5570-78-5 Process route
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-
5382-16-1
4-HYDROXYPIPERIDINE
-
-
67-64-1
acetone
-
-
5570-78-5
1-isopropylpiperidin-4-ol
| Conditions | Yield |
|---|---|
|
4-HYDROXYPIPERIDINE; acetone;
With
acetic acid;
In
tetrahydrofuran;
at 0 ℃;
for 0.25h;
With
sodium tris(acetoxy)borohydride;
In
tetrahydrofuran;
at 20 - 40 ℃;
for 2.75h;
With
ammonia;
In
water;
for 0.5h;
pH=9;
|
100%
|
|
4-HYDROXYPIPERIDINE; acetone;
With
acetic acid;
In
tetrahydrofuran;
at 0 ℃;
for 0.25h;
With
sodium tris(acetoxy)borohydride;
In
tetrahydrofuran;
at 20 - 40 ℃;
for 2.83333h;
With
ammonia; water;
for 0.5h;
pH=9;
|
100%
|
|
4-HYDROXYPIPERIDINE; acetone;
With
acetic acid;
In
1,2-dichloro-ethane;
at 20 ℃;
for 12h;
Inert atmosphere;
With
sodium tris(acetoxy)borohydride;
In
1,2-dichloro-ethane;
at 20 ℃;
for 12h;
|
29%
|
|
4-HYDROXYPIPERIDINE; acetone;
With
sodium sulfate;
In
chloroform;
at 20 ℃;
for 24h;
With
sodium tris(acetoxy)borohydride;
In
chloroform;
at 20 ℃;
With
methanol;
In
chloroform;
at 20 ℃;
|
|
|
4-HYDROXYPIPERIDINE; acetone;
In
1,2-dichloro-ethane;
at 20 ℃;
for 1.5h;
With
sodium tris(acetoxy)borohydride;
In
1,2-dichloro-ethane;
at 20 ℃;
for 18h;
|
-
-
5382-16-1
4-HYDROXYPIPERIDINE
-
-
75-26-3
isopropyl bromide
-
-
5570-78-5
1-isopropylpiperidin-4-ol
| Conditions | Yield |
|---|---|
|
With
potassium carbonate;
In
methanol;
Heating / reflux;
|
80%
|
|
With
potassium carbonate;
In
N,N-dimethyl-formamide; acetonitrile;
at 20 ℃;
for 12h;
|
35%
|
|
With
potassium carbonate;
In
methanol;
for 12h;
Reflux;
|
|
|
With
potassium carbonate;
In
methanol;
for 12h;
Reflux;
|
2.2 g
|
5570-78-5 Upstream products
-
5355-68-0
1-Isopropyl-4-piperidone
-
16217-23-5
3,3'-isopropylimino-di-propionic acid diethyl ester
-
5382-16-1
4-HYDROXYPIPERIDINE
-
67-64-1
acetone
5570-78-5 Downstream products
-
397275-42-2
4-[(1-isopropyl-4-piperidinyl)oxy]benzonitrile
-
397275-34-2
4-(1-isopropylpiperidin-4-yloxy)benzaldehyde
