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4-Methylthiosemicarbazide
- Name 4-Methylthiosemicarbazide
- CAS 6610-29-3
- Purity 99%
Product Details
4-Methylthiosemicarbazide 6610-29-3 with purity >99% Low price in stock
- Molecular Formula: C2H7N3S
- Molecular Weight: 105.164
- Appearance/Colour: white to almost white crystalline powder
- Vapor Pressure: 0Pa at 25℃
- Melting Point: 135-138 °C(lit.)
- Refractive Index: 1.553
- Boiling Point: 168.4 °C at 760 mmHg
- PKA: 11.45±0.70(Predicted)
- Flash Point: 55.6 °C
- PSA： 82.17000
- Density: 1.197 g/cm3
- LogP: 0.43610
4-Methylthiosemicarbazide(Cas 6610-29-3) Usage
|
Flammability and Explosibility |
Nonflammable |
|
General Description |
4-Methyl-3-thiosemicarbazide is a subject of considerable pharmacological interest owing to its wide range of biological effects. |
InChI:InChI=1/C2H7N3OS/c1-7-5-4-2(3)6/h5H,1H3,(H3,3,4,6)
6610-29-3 Relevant articles
DNA cleavage, antimicrobial, spectroscopic and fluorescence studies of Co(II), Ni(II) and Cu(II) complexes with SNO donor coumarin Schiff bases
Patil, Sangamesh A.,Naik, Vinod H.,Kulkarni, Ajaykumar D.,Badami, Prema S.
, p. 347 - 354 (2010)
A series of Co(II), Ni(II) and Cu(II) co...
Insight on a new indolinone derivative as an orally bioavailable lead compound against renal cell carcinoma
Fouad, Marwa A.,Zaki, Mayssoune Y.,Lotfy, Raghda A.,Mahmoud, Walaa R.
, (2021/06/15)
A series of novel 3-indolinone-thiazolid...
A novel 8-nitro quinoline-thiosemicarbazone analogues induces G1/S & G2/M phase cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway
Arasakumar, Thangaraj,Athimoolam, Shunmuganarayanan,Mohan, Palathurai Subramaniam,Saravanan, Arjunan,Shyamsivappan, Selvaraj,Suresh, Thangaraj,Vivek, Raju
, (2020/03/11)
A series of novel 8-nitro quinoline-base...
Synthesis and characterization of a new series of thiadiazole derivatives as potential anticancer agents
?evik, Ulviye Acar,Osmaniye, Derya,Levent, Serkan,Sa?lik, Begüm Nurpelin,?avu?o?lu, Betül Kaya,?zkay, Yusuf,Kaplancikl, Zafer Aslm
, p. 6 - 13 (2020/03/30)
Cancer is one of the most common causes ...
Novel Schiff bases derived from isothiocyanates: synthesis, characterization, and antioxidant activity
Yakan, Hasan
, p. 3979 - 3995 (2020/07/03)
A series of novel thiosemicarbazones inc...
6610-29-3 Process route
-
-
556-61-6
methyl thioisocyanate
-
-
6610-29-3
4-methylthiosemicarbazide
| Conditions | Yield |
|---|---|
|
With
hydrazine hydrate;
In
isopropyl alcohol;
at 0 - 20 ℃;
for 1.5h;
|
85%
|
|
With
ethanol; hydrazine hydrate;
|
|
|
With
hydrazine hydrate;
In
diethyl ether; ethanol;
|
|
|
With
hydrazine;
In
diethyl ether;
|
|
|
With
hydrazine hydrate;
ice-cold temperature;
|
|
|
With
hydrazine hydrate;
In
ethanol;
cooling;
|
|
|
With
hydrazine hydrate;
In
ethanol;
|
|
|
With
hydrazine hydrate;
In
ethanol;
Heating;
|
|
|
With
hydrazine hydrate;
In
ethanol;
Cooling with ice;
|
|
|
With
hydrazine;
|
|
|
With
hydrazine hydrate;
In
ethanol;
at 20 ℃;
Solvent;
|
|
|
With
hydrazine hydrate;
In
isopropyl alcohol;
for 0.5h;
|
|
|
With
hydrazine;
In
dichloromethane;
at 20 ℃;
for 2h;
|
|
|
With
hydrazine hydrate;
In
ethanol;
at 20 ℃;
|
|
|
With
hydrazine hydrate;
In
ethanol;
at 0 ℃;
for 1h;
|
-
-
75-15-0,12122-00-8
carbon disulfide
-
-
74-89-5
methylamine
-
-
6610-29-3
4-methylthiosemicarbazide
| Conditions | Yield |
|---|---|
|
carbon disulfide; methylamine;
In
ethanol; ammonia;
Cooling with ice;
With
sodium monochloroacetic acid; hydrazine hydrate;
In
ethanol; ammonia; water;
|
81%
|
|
carbon disulfide; methylamine;
With
triethylamine;
With
hydrazine hydrate;
In
water;
for 24h;
Reflux;
|
74%
|
|
carbon disulfide; methylamine;
With
sodium hydroxide;
In
water;
at 20 - 25 ℃;
for 2h;
With
hydrazine hydrate;
In
water;
for 6h;
|
71.1%
|
|
carbon disulfide; methylamine;
With
ammonium hydroxide;
In
ethanol;
at 0 - 20 ℃;
for 2.5h;
With
sodium monochloroacetic acid; hydrazine hydrate;
In
ethanol;
Heating;
|
48%
|
|
Multistep reaction;
(i) aq. NH3, (ii) ClCH2CO2Na, (iii) N2H4*H2O;
|
|
|
carbon disulfide; methylamine;
In
ethanol; ammonia; water;
for 3h;
Cooling with ice;
With
sodium monochloroacetic acid; hydrazine hydrate;
In
ethanol; ammonia; water;
for 3h;
|
6610-29-3 Upstream products
-
556-61-6
methyl thioisocyanate
-
13037-11-1
S-methyl N-methyl dithiocarbamate
-
75-15-0
carbon disulfide
-
74-89-5
methylamine
6610-29-3 Downstream products
-
6839-88-9
pyridine-2-carbaldehyde 4-N-methyl thiosemicarbazone
-
100057-69-0
acetic acid-[4-(4-methyl-thiosemicarbazonomethyl)-anilide]
-
2613-12-9
benzaldehyde N4 -methylthiosemicarbazone
-
51146-63-5
4-methoxy-benzaldehyde-(4-methyl thiosemicarbazone)
